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KMID : 1101420160480040280
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Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 4 p.280 ~ p.286
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Attenuation of Atherosclerosis by 3,4-Dihydroxy- Hydrocinnamic Acid in Rabbits by Partial Inhibition of ACAT
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Lee Mi-Ran
Choi Jae-Hoon
Yang Young
Oh Ki-Sook
Jeong Tae-Sook
Lee Chul-Ho
Oh Goo-Taeg
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Abstract
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Polyphenols have been reported to have beneficial effects on cardiovascular disease. A polyphenolic compound, 3,4-dihydroxy-hydrocinnamic acid (3,4-DHHCA), has been shown to have antioxidative and antitumorigenic activities. However, the effect of 3,4-DHHCA on atherosclerosis is still unknown. Herein, we investigated the effects of 3,4-DHHCA on atherosclerosis in New Zealand White rabbits. Broad and fused fatty streak lesions were found in rabbits fed with high-cholesterol diet for 8 weeks. Administration of 3,4-DHHCA reduced atherosclerotic lesion formation and lesional accumulation of macrophage in rabbits fed with cholesterol diet without systemic or local toxicity. Hepatic acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity was decreased after treatment with 3,4-DHHCA by 22% in cholesterol diet-fed rabbits compared with the control group. These results indicate that 3,4-DHHCA had antiatherogenic effects in rabbits, possibly by partial inhibition of ACAT.
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KEYWORD
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Atherosclerosis, 3, 4-dihydroxy-hydrocinnamic acid, Animal models, Acyl-CoA:cholesterol acyltransferase, High density lipoprotein
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